Developed by Treyarch and published by Activision, the game has you playing as Spider-Man in the events of the movie while also adding new enemies like the Shocker and Vulture. The gameplay consists of successive levels where you need to defeat thugs with your fists and web and save someone/something from multiple sources of danger until you reach the boss of the section. You either fight in enclosed environments or swing around New-York City in "aerial" sequences.

Spider-Man: Web of Shadows is a video game title encompassing three versions: a full-3D action game for Microsoft Windows, PlayStation 3, Wii, and Xbox 360; a 2.5D sidescrolling beat em up action game for the PlayStation Portable and PlayStation 2 (called Amazing Allies Edition), and a 2.5D side-scrolling brawler/platformer for the Nintendo DS. Spider-Man: Web of Shadows, along with most other games published by Activision that had used the Marvel licence, was de-listed and removed from all digital storefronts on January 1, 2014.

Starring the world’s most iconic Super Hero, Spider-Man features the acrobatic abilities, improvisation and web-slinging that the wall-crawler is famous for, while also introducing elements never-before-seen in a Spider-Man game. From traversing with parkour and utilizing the environment, to new combat and blockbuster set pieces, it’s Spider-Man unlike any you’ve played before.