Returning after his mother's murder to the semi-fictional city of Los Santos (based on Los Angeles), Carl Johnson, a former gang banger, must take back the streets for his family and friends by gaining respect and once again gaining control over the streets. However, a story filled with crime, lies and corruption will lead him to trudge the entire state of San Andreas (based on California and Nevada) to rebuild his life.

Resident Evil 4 is directly based off the Wii port, having all the new features that the Wii added. Some of the key features of this version are stunning HD graphics running at a smooth 60 frames per second for the first time. It also features a complete visual overhaul to bring this revered title to the highest graphical quality ever. It has been fully optimized for the wide screen, texts have been sharpened and textures have been upgraded on characters, backgrounds and in-game objects. However, it should be noted that the cutscenes of the Separate Ways scenario are not in HD and have had their resolution lowered and placed in sepia format. Aside from the updated HUD, the Movie Browser is fixed to now display real time cut-scenes instead of the PS2 pre-rendered cut-scene, like it was the Wii version. The Mercenaries costumes cheat remain and fully work.

Resident Evil 4 is a remake of the 2005 original Resident Evil 4 reimagined for 2023 to bring state-of-the-art survival horror. Resident Evil 4 preserves the essence of the original game, while introducing modernized gameplay, a reimagined storyline, and vividly detailed graphics to make this the latest survival horror game where life and death, terror and catharsis intersect.